A dermatologist names cancer as a possible cause of white peeling skin inside the lip.

In addition to having just brushed one’s teeth, which can cause cells inside the lip to slough off, other conditions can cause the inside of the lip to develop a white, peeling reaction.

“Lichen planus (LP) is a condition that can affect the mucus membranes of the mouth,” says Dr. Rebecca Tung, MD, director of the dermatology division at Loyola University Health System, Chicago.

“It often looks lacy in a lattice pattern. While most cases occur on their own as a result of a body’s altered immune response, other cases can be the result of sensitivity or allergy to metal in dental work, or even a skin finding of an infectious viral hepatitis (inflammation of the liver; hepatitis C).”

Cancer As Cause of White Peeling Inside the Lip

“A more serious white patch on the inside of the bottom lip could be skin cancer—specifically squamous cell carcinoma (SCC) or its precancerous state (leukoplakia),” says Dr. Tung.

“Smokers, tobacco chewers and heavy drinkers are at increased risk for SCC.

“A biopsy of the lesion can confirm the diagnosis and direct treatment.”

Dr. Tung’sdr. tung specialties include general dermatology with skin cancer surveillance, moles, melanoma, surgery (Mohs micrographic, laser, skin cancer reconstruction) and cosmetic dermatology.
Lorra Garrick has been covering medical, fitness and cybersecurity topics for many years, having written thousands of articles for print magazines and websites, including as a ghostwriter. She’s also a former ACE-certified personal trainer.  

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