Endometriosis not only can cause damage to the kidneys, but it can cause kidney LOSS.

The type of endometriosis that damages kidneys is called ureteral endometriosis.

A case report in the Journal of the Society of Laparoendoscopic Surgeons (July-Sept. 2012) details three cases of kidney shrinkage and loss of function due to endometriosis.

Basic Facts Every Woman Should Know

• 6-10 percent of premenopausal women get endometriosis.

• The condition means uterine-like tissue outside the uterus.

• This can occur to the lining of the abdomen, the ovaries and “extragenital,” meaning, beyond the genital region. This occurs in up to 12 percent of patients with endometriosis.

• Ureteral endometriosis affects 350,000 women worldwide.

• It often involves only one ureter. This can lead to a urinary tract infection or kidney (renal) loss.

• However, complete kidney loss to endometriosis is “exceedingly rare,” says the JSLS paper.

• Removal of the damaged kidney is the course of action after all other salvaging attempts and interventions have failed.

30 Percent Chance of Renal Failure

In ureteral endometriosis, the left ureter is more often affected simply due to anatomy.

The study authors (Nezhat et al) estimate that by the time a woman is diagnosed with UE, there will be a 30 percent chance that she’ll have impaired renal function.

The three patients of the study authors did not have an abnormal kidney function test (creatinine) because the unaffected kidney was fully functioning.

Thus, a normal creatinine result does not rule out UE damage to this organ. However, UE can also at times affect both kidneys.

Symptoms
• Whether unilateral or bilateral, the process in most cases is insidious or “silent.”

• 30 percent of patients will have nonspecific symptoms that are consistent with pelvic endometriosis. In very rare cases there are no symptoms.

• Some will have symptoms of bladder urgency, frequency, pelvic or flank pain, blood in the urine and painful urination.

• Because most genitourinary (relating to genital and urinary organs) symptoms relate to bladder-involved endometriosis and seldom arise from UE, a diagnosis of UE might be overlooked.

• The three patients in this study actually did not have any genitourinary symptoms, but all three did have pelvic pain, painful menstruation and vague back pain.

Endometriosis Affecting the Kidney:

Elusive Diagnosis

The physician needs to be suspicious of UE from a clinical standpoint, especially since UE occurs along with pelvic endometriosis.

So if the patient’s symptoms are consistent with the pelvic version, the physician needs to consider a possibility of ureter involvement. But this is easier said than done.

The imaging of choice to investigate suspected UE is pelvic ultrasound, intravenous pyelography, ureterostomy, MRI or CT scan.

Despite what these image studies can show, the paper reports that a diagnosis prior to surgery is difficult.

Final diagnosis requires revelation of a deeply infiltrative (i.e., deep within the organ) disease via a laparoscopy or biopsy.

Treatment for Kidney Damage from Endometriosis

• The objective is symptom relief (surgical excision is the most effective) and clearing the ureteral obstruction.

• Of course, all efforts will be made to salvage the affected kidney.

• Three medical specialists should be involved: laparoscopic gynecologist, urologist and colorectal surgeon.

• Laparoscopy, especially video-aided, is superior to conventional laparotomy.

Top image: Shutterstocks/sebra
Sources
ncbi.nlm.nih.gov/pmc/articles/PMC3535807/
brighamandwomens.org/Departments_and_Services/obgyn/Services/infertility-reproductive-surgery/endometriosis/infiltrative.aspx endometriosis kidney damage