There are reasons why you cannot count on an ultrasound for detecting gallbladder cancer; yet, it can also “miss” it.

Symptoms of Gallbladder Cancer

  • Abdominal pain, especially in the upper right area of the abdomen
  • Abdominal bloating
  • Fever
  • Unintentional or unexplained loss of weight
  • Nausea
  • Yellowing of the skin and of the whites of the eyes (jaundice)

The Ultrasound

“The usual diagnostic study for gallstone-related disease is ultrasonography (US),” says Akram Alashari, MD, abdominal surgeon and critical care physician, Department of Surgery, College of Medicine, University of Florida.

Many patients who have gallbladder cancer that is discovered by accident are found retrospectively to have had suspicious ultrasound findings (e.g., a solitary or displaced stone, or an intraluminal or invasive mass) that were not recognized preoperatively.

“Findings that are suggestive but not diagnostic of gallbladder cancer include mural thickening or calcification, a mass protruding into the lumen, a fixed mass in the gallbladder, loss of the interface between the gallbladder and liver, or direct liver infiltration,” explains Dr. Alashari.

Accuracy of the Ultrasound

“The overall accuracy of US for staging the local and distant extent of a suspected gallbladder cancer is limited,” says Dr. Alashari.

“In one report of 26 patients, accuracy was only 38 percent, and the sensitivity for detection of liver infiltration or nodal metastases was only 50 percent each.”

Risk Factors for Gallbladder Cancer

  • Aging
  • A history of gallstones, though it’s a small risk.
  • Non-stone gallbladder disease

Who Gets Gallbladder Cancer?

This disease is very uncommon. It’s so uncommon that the National Cancer Institute Surveillance and Epidemiology End Results Program includes it with liver cancer statistics.

  • About 37 percent of newly diagnosed cases each year in the U.S. are in people 55 to 64.
  • In people 45 to 54 it’s 12.1 percent.
  • In those 35 to 44 it’s 1.8 percent.
  • For those 20 to 34 it’s 0.7 percent.
  • For people under age 20 it’s 0.8 percent.

The symptoms of gallbladder cancer can also have benign causes.